NAD+
What is NAD+?
NAD stands for Nicotinamide Adenine Dinucleotide and is a pivotal coenzyme found in all living cells. Among its many functions, NAD+ is a necessary part of the biochemical reactions involved in metabolizing food for energy. NAD+ is also important for DNA repair which can ultimately affect overall health and longevity.
Compounded NAD+ formulations, particularly injectable forms, offer potential advantages in personalized medicine by allowing tailored dosing and delivery methods. Understanding the role of these compounded medications can enhance therapeutic outcomes in clinical practice.
Studied IV Benefits for NAD+
Higher Bioavailability
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IV NAD+ bypasses first-pass metabolism, ensuring greater systemic absorption.
Faster Onset
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Studies suggest that IV NAD+ raises blood NAD+ levels more quickly than oral supplementation (Mehmel et al., 2020).
More Predictable Outcomes
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Patients receiving IV NAD+ therapy often report more immediate symptom relief compared to oral forms (Grant et al., 2019).
References
1.Bogan, K. L., & Brenner, C. (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition. Annual Review of Nutrition, 28, 115-130. https://doi.org/10.1146/annurev.nutr.28.061807.155443
2. Grant, R., Berg, J., Mestayer, R., Braidy, N., Bennett, J., Broom, S., & Watson, J. (2019). A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+. Frontiers in Aging Neuroscience, 11, Article 257. https://doi.org/10.3389/fnagi.2019.00257
3. Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses. Nutrients. 2020 May 31;12(6):1616. https://pmc.ncbi.nlm.nih.gov/articles/PMC7352172/
4. Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019). NAD+ in brain aging and neurodegenerative disorders. Cell Metabolism,30(4), 630-655. https://doi.org/10.1016/j.cmet.2019.09.001
5. Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018). Chronic
nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications, 9, Article 1286. https://doi.org/10.1038/s41467-018-03421-7
6. Rajman, L., et al. (2018). Aging and longevity in the simplest animals and the quest for immortality. Cell Metabolism, 27(5), 954-963.
7. Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism, 27(3), 513-528. https://doi.org/10.1016/j.cmet.2017.11.002
Learn More About NAD+
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